Radon and lung cancer.

نویسندگان

  • Tarsheen K Sethi
  • Moataz N El-Ghamry
  • Goetz H Kloecker
چکیده

Lung cancer is the leading cause of cancer-related deaths worldwide. Radon exposure is the second leading cause of lung cancer, following tobacco smoke. Radon is not only an independent risk factor; it also increases the risk of lung cancer in smokers. Numerous cohort, case-control, and experimental studies have established the carcinogenic potential of radon. The possibility of radon having a causative effect on other cancers has been explored but not yet proven. One of the postulated mechanisms of carcinogenesis is DNA damage by alpha particles mediated by the production of reactive oxygen species. The latter are also thought to constitute one of the common mechanisms underlying the synergistic effect of radon and tobacco smoke. With an estimated 21,000 lung cancer deaths attributable to radon in the United States annually, the need for radon mitigation is well acknowledged. The Environmental Protection Agency (EPA) has established an indoor limit of 4 picocuries (pCi)/L, and various methods are available for indoor radon reduction when testing shows higher levels. Radon mitigation should accompany smoking cessation measures in lung cancer prevention efforts.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Assessment of lung cancer risk due to indoor radon exposure in inhabitants of the state of Azad Kashmir Pakistan

Background: Several epidemiological studies conducted on underground miner’s show that exposure to elevated levels of radioactive radon gas is expected to increase the risk of lung cancer. Relative risk of lung cancer is almost linear with radon exposure. Elevated concentrations of radon are not only reported within mines but also for closed indoor environment of general public houses....

متن کامل

Determination of Radon Gas Concentration in Fasa Residential Houses and the effects of inhalation on the incidence of lung cancer

Background & Objective: The present research project is based on the common ground in nuclear and medicine science. The purpose is to determine the concentration of radon gas in residential homes in Fasa in 1395 for investigating the effects of its inhalation on the incidence of lung cancer in residents of the home. Material & Methods: Among the residential houses, 10 houses were selected in di...

متن کامل

Investigating Indoor Radon Concentration Using CR-39 Detector; a Case Study of Gachin Dwellings in Hormozgan

Introduction: Radon is a colorless inert gas which decay products are the main component of natural radioactive elements that are naturally produced in under layers of earth crust by decay of radium and uranium. It enters through buildings via gaps and cracks. Radon gas decay products like alpha particle can increase the incidence of lung cancer in human. Since every person sp...

متن کامل

Indoor exposure assessment of radon in the elementary schools, Palestine

Background: Many public health agencies rank residential radon exposure as the second leading cause of lung cancer after cigarette smoking. It has been shown that the risk coefficient for lung cancer is higher for children than that for adults. Therefore, indoor radon measurements were carried out in the elementary schools of Tulkarem province, West Bank, Palestine. Materials and Methods: Two h...

متن کامل

Monte-Carlo Calculation of Radon Absorbed Dose in Optical Fiber as a Novel Method in Dosimetry and Radon Measurement

Introduction Radon is a colorless and tasteless gas which exists in most soils. It is a substance that poses a potential risk for lung cancer in case a person is exposed to high levels over long periods of time. The Environmental Protection Agency (EPA) estimates that 90% of lung cancers per year are caused by radon. The aim of this paper is to estimate the absorbed doses of 222Rn by MCNPX simu...

متن کامل

Health Assessment Based On the Exposure of Alpha Radioactivity in Narghile Smoking

Introduction: Smokers and non-smokers are at the risk of developing lung cancer when exposed to alpha rays as a result of the relatively low levels of radium and radon that may be present in different tobacco species. There is a great interest in studies and research on the radionuclides in narghile tobacco emitting alpha particles to know the relationship between smok...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical advances in hematology & oncology : H&O

دوره 10 3  شماره 

صفحات  -

تاریخ انتشار 2012